Search on: U1 SMALL NUCLEAR RIBONUCLEOPROTEINS 
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Descriptor English:   Ribonucleoprotein, U1 Small Nuclear 
Descriptor Spanish:   Ribonucleoproteína Nuclear Pequeña U1 
Descriptor Portuguese:   Ribonucleoproteína Nuclear Pequena U1 
Synonyms English:   Small Nuclear Ribonucleoproteins, U1
U1 snRNP
U1 Small Nuclear Ribonucleoproteins  
Tree Number:   D12.776.157.725.500.875.600
D12.776.664.962.500.875.600
Definition English:   A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction. 
History Note English:   2000; U1 SNRNP was U1-RNP (SY) to SMALL RIBONUCLEOPROTEINS (NM) 1982-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30535 
Unique Identifier:   D017412 

Occurrence in VHL:
 

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